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Home page > Research interest > Recoding to study translation

Recoding to study translation

It is essential for all living cells to accurately transfer the information contained in genes to proteins. Spontaneous errors can occur during all steps of translation on every mRNA and generally leads to non-functional protein. Instead, recoding events are restricted to a subset of mRNA and produce a new phenotype.

- Among the recoding sites identified programmed frameshift (PRF) are the most frequently found signals. They are minimally formed by a slippery sequence where tRNAs shift of the reading frame, and a stimulatory element (mainly a secondary structure).

- Recoding motifs can also be found at the termination codon, so they can be used to study termination reaction, which is particularly weakly understood in eukaryotes.